BookErwin G. Van Meir, editor.
Summary: Covers three areas of research in brain tumors: a) animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; b) Prognostic factors and biomarkers; c) Therapeutic targets and targeting approaches to brain tumors.
Contents:
Part I. Animal Models for central nervous tumors
Modeling gliomas using PDGF-expressing retroviruses
Modeling brain tumors using avian retroviral gene transfer
Using neurofibromatosis type 1 mouse models to understand human pediatric low-grade gliomas
Transgenic mouse models of CNS tumors: using genetically engineered murine models to study the role of p21 Ras in glioblastoma multiforme
PTEN-deficient mouse models for high-grade astrocytomas
The Nfl-/+; Trp53-/+cis mouse model of anaplastic astrocytoma and secondary glioblastoma : dissecting genetic susceptibility to brain cancer
Modeling astrocytomas in a family of inducible genetically engineered mice : implications for preclinical cancer drug development
Human brain tumor cell and tumor tissue transplantation models
Transformed human brain cells in culture as a model for brain tumors
Rat glioma models for preclinical evaluation of novel therapeutic and diagnostic modalities
Neuro-oncogenesis induced by nitroso compounds in rodents and strain-specific genetic modifiers of predisposition
The murine GL261 glioma experimental model to assess novel brain tumor treatments
Spontaneous occurrence of brain tumors in animals: opportunities as preclinical model systems
Part II. Prognostic factors and biomarkers
p53 pathway alterations in brain tumors
The PTEN/P13 kinase pathway in human glioma
Value of 1p/19q and other LOH markers for brain tumor diagnosis, prognosis, and therapy
Discovery of genetic markers for brain tumors by comparative genomic hybridization
Genomic identification of significant targets in brain cancer
Oncomodulatory role of the human cytomegalovirus in glioblastoma
Aberrant EGFR signaling in glioma
Mechanisms of brain tumor angiogenesis
Vaso-occlusive mechanisms that intiate hypoxia and necrosis in glioblastoma: the role of thrombosis and tissue factor
Transcription profiling of brain tumors: tumor biology and treatment stratification
Proteomic profiling of human brain tumors
Proteomic discovery of biomarkers in the cerebrospinal fluid of brain tumor patients
Epigenetic profiling of gliomas
Micronase in the central nervous system and potential roles of RNA interference in brain tumors
Of Escherichia coli and man : understanding glioma resistance to temozolomide therapy
Brain tumor stem cell markers
Part III. Therapeutic targets and targeting approaches
Clinical agents for the targeting of brain tumor vasculature
Bone marrow-derived cells in GBM neovascularization
Vascular targeting of brain tumors--bridging the gap with phage display
Impact of the blood-brain barrier on brain tumor imaging and therapy
Targeting CXCR4 in brain tumors
Molecular targeting of IL-13R[alpha]2 and EphA2 receptor in GBM
Molecular targets for antibody-mediated immunotherapy of malignant glioma
Stat3 oncogenic signaling in glioblastoma multiforme
Inhibition of Ras signaling for brain tumor therapy
HGF/c-Met signaling and targeted therapeutics in brain tumors
Combinatorial therapeutic strategies for blocking kinase pathways in brain tumors
Targeting the TRAIL apoptotic pathways for glioblastoma therapies
The NF-[kappa]B signaling pathway in GBMs : implications for apoptotic and inflammatory responses and exploitation for therapy
Targeting endoplasmic reticulum stress for malignant glioma therapy
Brain cancer stem cells as targets of novel therapies
The use of retinoids as differentiation agents against medulloblastoma
Herpes simplex virus 1 (HSV-1) for glioblastoma multiforme therapy
The development of targeted cancer gene-therapy adenoviruses for high-grade glioma treatment
Harnessing T-cell immunity to target brain tumors
Glioma invasion : mechanisms and therapeutic challenges.